Search results for "Umbilical cord mesenchymal stem cell"

Energy Metabolism Analysis of Three Different Mesenchymal Stem Cell Populations of Umbilical Cord Under Normal and Pathologic Conditions

2020

AbstractHuman umbilical cord mesenchymal stem cells (hUC-MSCs) are a pivotal source of therapeutically active cells for regenerative medicine due to their multipotent differentiation potential, immunomodulatory and anti-inflammatory proprieties, as well as logistical collection advantages without ethical concerns. However, it remains poorly understood whether MSCs from different compartments of the human umbilical cord are therapeutically superior than others. In this study, MSCs were isolated from Wharton’s jelly (WJ-MSCs), perivascular region (PV-MSCs) and cord lining (CL-MSCs) of hUC. These cells expressed the mesenchymal markers (CD90, CD73), stemness marker (OCT4), endothelial cell adh…

CHARACTERIZATION AND ENERGETIC METABOLISM ANALYSIS OF DIFFERENT POPULATIONS OF UMBILICAL CORD MESENCHYMAL STEM CELLS FOR THE TREATMENT OF STROKE

Stroke is a leading cause of death and disability worldwide. A direct consequence of oxygen and glucose deprivation during stroke is the dysfunction of mitochondria that impairs oxidative metabolism and contributes to oxidative stress, neuronal death and inflammation. Human umbilical cord (UC)-derived MSCs (UC-MSCs) are an attractive source for regenerative medicine purposes due to their self-renewal and multipotent differentiation potential, immunomodulatory and anti-inflammatory abilities. Notably, because UC is supplied from only three blood vessels, the UC-MSCs are physiologically adapted to survive in a relatively hypoxic and glucose poor environment leading to the hypothesis that thes…